全肠道外营养在新生儿破伤风治疗中的应用

Application of total parenteral nutrition in neonatal tetanus

目的 :探讨全肠道外营养 (TPN)在新生儿破伤风治疗中的应用效果。方法 :37例新生儿破伤风患者 ,在综合治疗 (镇静止痉、破伤风抗毒素及抗生素应用等 )的基础上给予TPN支持 (TPN组 ) ;TPN主要成分有葡萄糖、电解质、氨基酸、维生素混合液及脂肪乳剂 ,从周围静脉输入。另有32例新生儿破伤风给予综合治疗和部分静脉营养 (对照组 )。结果 :在TPN组中 ,体重增加 33例 ,对照组中 ,体重增加 18例 ,差异具有显著性 (χ2 =5 6 80 7,P <0 0 2 5 )。TPN组治愈 35例 ,死亡 2例 ,对照组治愈 2 5例 ,死亡 7例 ,差异具有显著性意义 (χ2 =4 10 37,P <0 0 5 )。TPN组治疗过程中未发现明显不良反应和合并症。结论 :TPN应用于新生儿破伤风患儿 ,安全方便 ,能够提供足够和平衡的营养 ,辅助提高疗效。

Aim: In order to explore the application and effect of total parenteral nutrition (TPN) in the treatment of neonatal tetanus. Methods: 37 neonates with tetanus received TPN which contains glucose, electrolytes, amino acids, vitamin and lipids on the basis of comprehensive treatment. Other 32 neonates tetanus who were only given partisl parenteral nutrition besides comprehensive treatment as control group. Results: In the TPN group, body weight increase was seen in 33 cases and in control group, only 18 cases. There was a significantly difference (χ~2=5.680 7,P<0.025)between two groups. 35 of 37 cases were cured and 2 died in TPN group. But in control group, 25 were cured and 7 died which also showed a statistically difference(χ~2=4.1037,P<0.05). Conclusion: TPN provides enough and balanced nutrition without side effect and is helpful for increasing treatment effect of neonates tetanus as well as its using is safe and convenient.