FHIT抑癌基因在头颈部鳞癌中的研究进展(综述)

The recent situation of study on the tumor suppressor gene FHIT in head and neck squamous cell carcinoma (A review)

脆性组氨酸三联体基因 (FHIT)是 1996年新发现的一种定位于人类染色体 3p14 .2上的抑癌基因 ,其编码的蛋白质具有ApnA水解酶的特性 ,可通过水解ApnA(主要是Ap3A)而阻止细胞生长信号传导途径 ,从而抑制细胞的生长 ;另有观点认为FHIT可与Ap3A等结合成FHIT底物复合物 ,这种复合物可能是一种信号物质 ,其抑癌作用可能比其水解酶作用更重要。研究表明FHIT在肿瘤的发生中起着重要的作用 ,现就FHIT在头颈部鳞癌中的研究进展作一综述。

In 1996, a new suppressor gene FHIT is found located at 3p14.2,which encodes a protein that have the property to hydrolyze the ApnA, and thence inhibit the growth of cells. Another point is that FHIT can be combined with Ap3A to form a FHIT complex, which may be a signal substance. This function may be more important than the function of hydrolyzing. Many studies have shown that FHIT plays an important role in the process of the tumorigenesis, and is closely related to the head and neck squamous cell carcinomas.