次声作用后大鼠下丘脑血管紧张素Ⅱ含量的改变

Change of angiotensin Ⅱ in hypothalamus of rats exposed to infrasound

目的 :观察次声作用后大鼠下丘脑血管紧张素 (Ang )含量的变化。方法 :用 16 Hz,(130 d B和 90 d B)次声连续作用 1,7,14,2 1次 ,2 h/次。每月 1次。分别于作用后 0 .5 ,6 ,12 ,18,2 4h观察大鼠下丘脑 Ang 含量。结果 :130 d B次声作用 1,14,2 1次和 90 d B次声作用 7,2 1次后 ,大鼠下丘脑 Ang 含量均经历升高 ,下降 ,复呈升高的动态变化过程。 130 d B次声作用 7次后大鼠下丘脑 Ang 含量呈持续性升高。 90 d B次声作用 1,14次后 ,大鼠下丘脑 Ang 含量呈升高和下降的单峰曲线 ,且 14次组于次声停止作用后 12 h已与对照组之间的差异无显著性意义。结论 :不同声强和作用次数的次声 ,对大鼠下丘脑 Ang 含量的影响呈波动性改变。

AIM: To observe the change of angiotensin Ⅱ (AngⅡ) in hypothalamus of rats exposed to infrasound. METHODS:The rats were exposed to infrasounds (frequence:16 Hz; acotustic pressure:130 dB and 90 dB), for 1,7,14,and 21 d,2 h daily, then AngⅡ contents were measured 0.5,6,12,18,and 24 h after the exposure. RESULTS: AngⅡ varied regularly, increasing firstly,then decreasing, and increasing again,after rats exposed to infrasound either with 130 dB for 1,14 and 21 d or with 90 dB for 7 and 21 d. In rats exposed to infrasound with 130 dB for 7 d AngⅡ increased continuously. After the exposure to infrasound with 90 dB for 1 and 14 d, AngⅡ of rats presented on the peak curve, and 12 h after the group were exposed to infrasound for 14 d, no signficant difference was detected between the exposure and the control groups. CONCLUSION: The content of AngⅡ in the hypothalamus of rats affected by the infrasounds with different sound intensities and by different numbers of exposures was fluctuated.