血管紧张素Ⅱ-1型受体基因多态性与冠状动脉血管病变及支架内再狭窄的关系

The relationship between angiotensin Ⅱ type Ⅰ receptor gene polymorphism and coronary atherosclerosis and in-stent restenosis

目的 :探讨血管紧张素 - 1型受体 (AT1 R)基因的 A116 6 C多态性与冠状血管动脉硬化进程以及支架术后血管内膜增殖的相关性。方法 :对 10 6例接受冠状动脉血管造影 (CAG)和支架术的患者 ,采用 PCR进行 A116 6 C多态性检测 ,并对其中 6 0例患者于半年内行 CAG随访 ,按 CAG结果分为再狭窄组与无再狭窄组。判定血管动脉硬化进程及再狭窄与 AT1 R A116 6 C多态性的相关性。结果 :10 6例患者中无 AT1 R CC基因型。 AT1 R AA和 AC型患者术前参照血管直径及最小管腔直径均无差异 ,血管平均狭窄程度也无差异 (P>0 .0 5 )。再狭窄组中 AA,AC和CC基因型频率分别为 0 .941,0 .0 5 9和 0 .0 0 0 ,而无再狭窄组分别为 0 .885 ,0 .115和 0 .0 0 0 ,两组间无显著性差异(χ2 =0 .6 17,P=0 .432 )。再狭窄组 116 6 C等位基因频率为 0 .0 2 9,无再狭窄组为 0 .0 5 8,无显著性差异 (χ2 =0 .5 9,P=0 .44 2 )。结论 :AT1 R A116 6 C多态性与血管动脉硬化进程及支架术后内膜的增殖无相关性。

AIM:To investigate the relationship between the angiotensin Ⅱ typeⅠ receptor gene and coronary atherosclerosis,and its effect on in-stent restenosis. METHODS:In this study AT 1R gene polymorphisms were investigated in 106 corpnary artery disease patients,among which 60 patients were again taken angiography in 6 months after stent placement. These polymorphisms were analysed by PCR and restriction fragment length polymorphism(RFLP). RESULTS:No AT 1R CC genotype was detected in our study. The study shows there were no statistically significant difference in reference diameter,minimal lumen diameter and the degree of mean segment diamter before PTCA between AT 1R AA and AC groups. In restenosis group,the AT 1R AA,AC and CC genetype frequenty were 0.941,0.059 and 0.000,against 0.885,0.115 and 0.000,respectively in nonrestenosis group ( χ 2=0.617,P=0.432). The frequency of 1166C allele was 0.029 in restenosis group against 0.058 in non-restenosis group(χ 2=0.59,P=0.442). CONCLUSION:The frequency of AT 1R genotype and C1166 allele was neither associated with the progression of coronary atherosclerosis nor with the in-stent restenosis.