中医药治疗腰椎间盘突出症外周血PLA_2活性的观测及相关临床研究

Clinical Study of the PLA_2 Activity in Serum of Lumbar Disc Herniation by Treatment of T.C.M

目的 :探讨和观察腰椎间盘突出症的化学性炎症反应在外周血中的表达。方法 :采用微孔比色法检测腰椎间盘突出症患者中医药治疗前后外周血PLA2 的活性 ,并进行相关临床统计分析。结果 :(1 )治疗前后外周血PLA2 活性的下降无统计学意义。 (2 )外周血PLA2 的活性与临床体征和影像学表现无明显的相关性。结论 :(1 )腰椎间盘突出症以局部的炎症反应为主。 (2 )外周血PLA2的活性不能做为判断炎症程度的指标。

Objective:To analysis the expression of the PLA_2 activity in serum of lumbar disc herniation (LDH) by treatment of T.C.M.Methods:The PLA_2 activity was biochemically assayed, and the clinical significance was statistically analyzed.Results:(1)There was no statistically significance of the variation of the PLA_2 activity in serum of LDH by treatment of T.C.M.(2) The PLA_2 activity in serum of LDH was negtive correlations with the clinic and image data.Conclusion:(1)The local inflammtory reaction may play an important role in the mechanism of LDH.(2) The synovial PLA_2 activity don't judge the inflammatory status of LDH.