射频消融术治疗快速型心律失常及对心脏急性期损伤的临床研究

Evaluation of Effect of Radiofrequency Ablation on Tachyarrhythmia and Cardiac Acute Injury

目的 探讨射频消融术 (RFCA)治疗快速性心律失常的疗效及对心脏急性期损伤的研究。方法 按常规方法进行心内膜标测及消融 ,并通过RFCA对心脏自主神经功能的影响、对心脏收缩功能的影响及射频电流对心脏的损伤作用和RFCA前后肌钙蛋白和SOD、内皮素的变化来研究RFCA对心脏的急性期损伤。结果 3 8例快速性心律失常患者均行RFCA术 ,全部获成功 ,总有效率达 10 0 %,无严重并发症。RFCA术后LF及HF均较术前明显降低 ,房早、室早在RFCA术前、后无明显差异 ,心脏收缩功能术前后无明显变化 ,SOD、内皮素术后明显高于术前。结论 RFCA是一种疗效优、副作用少、可根治的治疗快速性心律失常的首选方法 ,值得推广 ;RFCA确对心脏急性期有损伤 。

Objective To evaluate the efficacy of radiofrequeney ablation on tachyrhythmia and cardiac acute injure.Methods Endomyocardin was signified and ablated using routine methods,the effects of radiofrequency ablation on cardiac autonomic nerve function,cardiac systolic function,radiofrequency electric injury and changes of troponin,SOD and endothelin level in pre-operation and post-operation were evaluated to study RFCA procedure caused cardiac acute injury.Results Thirty-eight patients with tachyarrhythmia underwant RFCA.The successful rate was 100%,and none had serious complications.Postoperative LF and HF were reduced significantly as compared with preoperation,Atrium and ventricle premature beats had no significant difference before and after RFCA.Cardiac systolic function had no significant changes before and after procedure,but troponin,SOD and endothelin levels were significantly higher in postoperation than those of preoperation.Conclusions RFCA is a principal therapy of tachyarrhythmia because its excellent therapeutic effect,less side effect and eradication,RFCA has acute cardiac injury,but the injury is slight.