系统性红斑狼疮与EB病毒感染相关性研究

CORRELATION BETWEEN SYSTEMIC LUPUS ERYTHEMATOSUS AND EPSTEIN -BARR VIRUS INFECTION

目的 :探讨系统性红斑狼疮 (SLE)与EB病毒感染的相关性。方法 :用标准ELISA和PCR法检测 117例未成年SLE患者和 15 3名未成年正常对照、以及 196例成人SLE患者和 392名成人正常对照的EBV感染情况。结果 :未成年组 116例患者 (116 /117)和 10 7名对照 (10 7/15 3)EBV -IgG阳性 (P <0 .0 0 1) ,成年组 195例患者 (195 /196 )和 370名对照 (370 /392 )EBV -IgG阳性 (P =0 .0 14 ) ;随机抽取各 32例 ,患者和对照EBV -DNA阳性为 32、2 3例 (P <0 .0 2 )。结论 :EB病毒感染与SLE相关 ,EB病毒感染可能是SLE的其中一个病因。

Objective:To investigate the correlation between Epstein-Barr virus infection and SLE.Methods: We tested 117 young SLE patients & 153 matched young controls and 196 adult SLE patients & 392 normal adult controls for evidence of previous infection with EBV by standardized enzyme-linked immunosorbent assays and PCR.Results:Virtually all (116 of 117,or 99%) of these young patients had seroconverted against Epstein-Barr virus, as compared with only 70% (107 of 153) of their young controls ( P< 0.001); of the 196 adult lupus patients tested, all but 1 had been exposed to EBV, while 22 of the 392 adult controls did not have EBV antibodies ( P< 0.014). An assay for EBV DNA in lymphocytes established EBV infection in all random 32 of the young lupus patients tested, while only 23 of 32 matched controls were infected ( P <0. 02).Conclusions:There is a correlation between EBV and SLE, and EBV infection is probably an etiologic factor in SLE.