摘要
以苯酞和邻甲酚为起始原料 ,生成物经酰氯化、酰氰化、水解反应得苯基草酸甲酯衍生物 ,再与甲氧基氨盐酸反应得Z/E构型混合物。该混合物经转位反应得苯氧菌酯。反应总收率为 5 7 2 % (以苯酞计 ) ,产品纯度为 95 %。该工艺流程简单 。
Kresoxim methyl was prepared by reacting the intermediate, methyl 2 (2 methylphenoxymethyl) phenylglyoxylate, with O-methylhydroxylamine hydrochloride. The resulting E/Z isomer mixture was treated with hydrochloride for substantial rearrangement of the Z to the E isomer. The intermediate was synthesized by using O cresol, phthalide, thionyl chloride, and sodium cyanide as raw materials. The total yield of the five steps reaches 57.2% (according to phthalide), and the process is convinient and suitable for the industrial manufacture.
出处
《精细化工中间体》
CAS
2003年第4期10-11,共2页
Fine Chemical Intermediates
关键词
苯氧菌酯
邻甲酚
苯酞
合成
Kresoxim-methyl
O cresol
phthalide
synthesis
