载药淀粉微球合成条件的研究

Study on synthesis of holding-drug-starch microsphere

为了解决靶向给药的难题,以马铃薯淀粉为原料,选用新型的交联剂、乳化剂,以吸附量为指标,进行正交试验。结果表明,载药淀粉微球的最佳合成条件为:淀粉7g,加水65ml,搅拌成糊状,用NaOH调节pH=8～9,于80℃下活化0.5h。在三口烧瓶中加入0.4g乳化剂,加入100ml植物油,60℃下使乳化剂溶解,加入淀粉,搅拌。用显微镜观察淀粉的分散性,当达到要求后,加入1.2g交联剂、0.6g引发剂,于55℃下反应3h。该产品有效的解决了药物的靶向性,大大提高了药物的疗效,降低了药物对人体的副作用。

To solve the problem of targeting direction of medicine, potato starch as the raw material and choose new style crosslinking agent and emulgent.The orthogonal experiment is made with the adsorption as the target.The results showed that the optimum conditions for synthesizing holdingdrug starch microsphere were as follows: starch 7 g , add the water 65 ml and agitate until to paste , regulate the pH=8～9 with sodium hydroxide , activate 0.5 h at 80 ℃. Solve 0.4 g emulgent with 100 ml plant oil at 60 ℃ in the three mouth flask, then add starch and agitate,observe the starch dispersion through the microscope, when it attains to requirement ,add 1.2 g crosslinking agent,0.6 g initiator,reaction for 3 h at 55 ℃. The product effectively solved the problem of targeting direction of medicine, and increased the healing effects of the medicine while decreasing the reverse effects for human being.