IPED方案治疗难治性非何杰金氏淋巴瘤的近期疗效

Short-term effect of IPED regimen in treatment of refractory Non-Hodgkun's lymphoma

目的 观察由异环磷酰胺 (IFO)、足叶乙甙 (VP 16 )、顺铂 (DDP)和地塞米松 (DXM )组成的联合方案 (IPED方案 )治疗难治性非何杰金氏淋巴瘤的近期效果和毒副作用。方法 2 1例难治性非何杰金氏淋巴瘤均采用IPED方案进行化疗 ,每 2 8天重复 ,每例至少进行化疗 2个周期 ,治疗结束后评价疗效。结果 CR 5例 ,PR 10例 ,SD 3例 ,PD 3例 ,总有效率为 71.4 % ,毒副作用主要为骨髓抑制和消化道反应。结论 IPED方案是治疗难治性非何杰金氏淋巴瘤效果较好、毒副反应可以耐受的联合化疗方案。

Objective To observe the effect and toxicity of IPED regimen in treatment of refractory Non-Hodgkin's Lymphoma.Methods All 21 patients were treated over two cycles with IPED regimen. The IPED regimen was repeated every 28 days. The therapeutic effect was observed after treatment.Results 5 patients achieved complete remission(CR) ,10 partial remission(PR) 3 stable disease(SD),3 progression disease(PD). The overall response rate was 71.4%.The main side effects were myelosuppression and gastrointestinal reaction.Conclusion The IPED regimen is effective in the treatment of refractory Non-Hodgkin's lymphoma and it's toxicity is tolerable.