异丙酚和硫贲妥钠对贲门癌根治术患者血清IL-8、IL-10、GST的影响

The effect of propofol and thiopentone on serum IL-8、IL-10 and GST of patients undergoing operative for cardiac cancer radical surgery

目的 异丙酚和硫贲妥钠在贲门癌根治术中应用 ,观察围术期IL 8、IL 10、GST的变化。方法贲门癌根治术患者 4 0例 ,分异丙酚 (P组 )和硫贲妥钠 (T组 ) ,麻醉前后抽取静脉血 ,检测血清IL 8、IL 10、GST。结果 术后血清IL 8、IL 10、GST高于麻醉前 ,P组血清IL 8、GST低于T组 ,而IL 10高于T组。结论 异丙酚能调控贲门癌患者围术期IL 8、IL 10的分泌 ,有效抑制GST分泌保护肝脏功能。

Objective To observe the changes of interleukin 8(IL-8),interleukin 10 (IL-10) and glitathione S-transferases(GST) of patients undergoing gastric cardiac cancer radial surgery by propofol and thiopentone.Methods Forty patients undergoing cardiac radical surgery were divided into group P (propofol) and group T (thiopentone), the contents of IL-8, IL-10 and activity of GST in blood samples were measured.Results The contents of IL-8, IL-10 and the activity of GST were higher than that of 5 minutes before anesthesia.The contents of IL-8 and the activity of GST in group T was significant higher than that of group P.The contents of IL-10 in group P was significant higher than that in group T.Conclusion Popofol can modulate the production of IL-8 and IL-10, and protect the hepatic function.