雌、孕激素拮抗剂对卵巢上皮癌细胞系体外增殖的作用

The effect of antiestrogen and antiprogestin on ovarian epithelial cancer cell lines in vitro

目的 探讨雌、孕激素拮抗剂对卵巢上皮癌细胞系的作用。方法 采用多种技术分析了雌、孕激素受体在卵巢上皮癌细胞系中的表达以及雌、孕激素拮抗剂对卵巢上皮癌细胞体外增殖的影响。结果 卵巢上皮癌细胞系SKOV3ER(+) /PR(- ) ;OVCAR 3ER/PR均阳性 ;高剂量的他莫昔芬可抑制两种细胞的增殖 ;而米非司酮仅抑制OVCAR 3细胞生长。结论 雌、孕激素拮抗剂可抑制卵巢上皮癌细胞系体外增殖 ,其作用与受体表达相关。

Objective To observe the effect of antiestrogen and antiprogestin on the proliferation of ovarian epithelial cancer (OEC) cell lines in vitro. Methods A variety of protocols were utilized to conduct this study. Results OEC cell line SKOV3 is ER(+)/PR(-), while OVCAR-3 is ER(+)/PR(+). High dose of tamxifen inhibited the proliferation of both cell lines, while mifepristone only inhibited OVCAR-3. Conclusion Antiestrogen and antiprogestin can inhibit the proliferation of some ovarian epithelial cancer cell lines in vitro.