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STAT3与VEGF在非小细胞肺癌中的表达及关系 被引量:5

Relationship of STAT3 and VEGF in non-small cell lung cancer
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摘要 目的 :探讨非小细胞肺癌中STAT3蛋白与VEGF表达的关系 ,以进一步探讨肿瘤的发生及转移机制。方法 :利用SABC免疫组织化学技术检测 4 0例非小细胞肺癌 (NSCLC)组织中STAT3蛋白和VEGF的表达。结果 :(1)STAT3在低分化肺癌组织中的表达明显高于高分化肺癌组织 ,在有淋巴结转移肺癌组织中的表达明显高于无淋巴结转移肺癌组织 ,与肿瘤的大小及组织学类型无关。 (2 )VEGF在直径≥ 3cm肺癌组织中的表达明显高于直径 <3cm肺癌组织 ,在有淋巴结转移肺癌组织中的表达明显高于无淋巴结转移肺癌组织 ,与肿瘤的组织学类型及分化程度无关。 (3)STAT3与VEGF表达呈显著正相关。结论 :本组资料提示STAT3与VEGF可能在肺癌的发生及转移中发挥重要作用。二者之间的相关性证实VEGF基因直接由STAT3蛋白调节的论点。由此也为目前肿瘤抗血管生成治疗的研究提供了新的证据。 Objective:To explore the expression of STAT3 and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC) and their relationship.Methods:SABC immunohistochemistry was used to detect the expression of STAT3 and VEGF in non-small tissues of 40 cases.Results:(1)The expression of STAT3 in NSCLCs had a obvious relation with the tumor cell differentiation and lymph node metastasis.No obvious difference in STAT3 expression was found among different tumor sizes of tumor types.(2)The expression of VEGF in NSCLCs had a significant relation with tumor size and lymph node metastasis.There was no significant difference between VEGF expression and tumor types and tumor cell differentiation.(3)There was significant positive correlation between the expression of VEGF and STAT3 in NSCLCs.Conclusion:STAT3 and VEGF may play an important role in the development of NSCLC.We identify that VEGF gene is regulated directly by STAT3 protein.
出处 《重庆医科大学学报》 CAS CSCD 2003年第4期460-462,466,共4页 Journal of Chongqing Medical University
关键词 非小细胞肺癌 STAT3 VEGF 免疫组化 Non-small cell lung cancers Signal transducers and activators of transcription 3 Vascular endothelial growth factor Immunohistochemistry
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