膀胱癌组织中MMP9、MMP2与PCNA及临床指标的研究

Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder

目的 :探讨基质金属蛋白酶 (MMP9、MMP2 )在膀胱癌组织中的表达及意义。方法 :采用免疫组织化学S -P法检测6 4例人膀胱移行细胞癌 (TCCB)石蜡切片中MMP9、MMP2的表达。结果 :6 4例TCCB组织中 ,MMP9、MMP2的阳性表达率分别为 6 0 .93% (39/6 4 )、4 2 .19% (2 7/6 4 ) ;且MMP9的阳性表达率与肿瘤的病理分级和分期 ,以及肿瘤的大小及PCNA的阳性表达率相关 ;与年龄、性别、肿瘤数目无关。结论 :MMP9的表达可以作为估计TCCB的预后及术后综合治疗的生物学指标。

Objective:To study the expression and clinical significance of matrix metalloproteinase(MMP9,MMP2)in transitional cell carcinoma of bladder(TCCB).Methods:Applying S-P immunohistochemical technique,expression of MMP9 and MMP2 was studied in 64 TCCB.Results:There was 60.93%(39/64) with MMP9 and 42.19%(27/64) with MMP2 expression.There was a significant correlation between MMP9 expression and PCNA,pathological grade,clinical stage,tumor size.However,the relationship had not been found with patient age,sex as well as the number of tumor.Conclusion:MMP9 appears to be an independent biological marker for predicting prognosis and comprehensive treatment of TCCB.