尿微量蛋白的检测对早期糖尿病肾病的诊断价值

The diagnostic value of microalbuminuria in early diabetic nephropathy

目的 :探讨尿微量蛋白的定量检测对糖尿病肾病的早期诊断的意义。方法 :利用速率免疫散射比浊法检测 6 5名糖尿病人以及 5 0名正常健康人的 2 4h尿中α1-微球蛋白 (α1-MG)、免疫球蛋白G(IgG)、尿微量白蛋白 (MA)、尿转铁蛋白(TRF)的含量。结果 :6 5名糖尿病人较 5 0例正常健康人尿微量白蛋白显著增高 (P <0 .0 1) ,其他 3种蛋白也明显增高 (P <0 .0 1)。结论 :进行尿微量蛋白的检测有助于了解糖尿病病人早期肾受损的情况。联合检测尿中MA、α1-MG、IgG、TRF可提高糖尿病肾病的早期诊断以及对疾病的治疗及转归有着重要的价值。

Objective:To study the significance of microalbuminuria in the diagnosis of early diabetic nephropathy.Methods:24 hour urine α 1-microglobulin(α 1-MG),urine immunoglobulin G(IgG),urine microalbumin (MA) and urine transferrin(TRF) in 65 diabetic patients and 50 normals were detected by rate immunonephelometery method.Results: The urine MA in 65 diabetic patients was significantly higher than that in 50 healthy persons ( P <O. O1),and the other three proteins were obviously higher too ( P <O. O1).Conclusion: The urine MA is a good index of the early kidney injury in diabetic patients.The combined detection of urine MA, α 1-MG, IgG and TRF can improve the early diagnosis of diabetic nephropathy, and these indexes have important value in therapy.