相关分析在建立基因调控网络中的应用

The Construction of Gene Network by Correlation Analysis

目的 讨论利用模糊相关系数建立基因调控网络。并从理论和实际应用的角度和其他相关系数方法进行相互比较。方法 以基因表达数据矩阵为出发点 ,用相关系数描述基因之间的相互关系 ,并在某一阈值下 ,建立起基因调控网络图。结果 用模糊相关系数对RatCNS数据集建立起调控网络图。结论 通过分析发现相关系数是构建基因调控网络的一个有效的工具。但不同的方法有其各自的特点 ,应根据不同情况采用不同的方法。

Objective To construct the gene network by Fuzzy correlation matrix.And compare this method with other correlation methods.Methods Based on gene expression matrix,correlation number is used to describe the relationships between genes.At some threshold,the gene network can be established.Results The gene network of Rat CNS was got by Fuzzy correlation matrix.Conclusion The correlation analysis is a very powerful tool to construct the gene network.But the different correlation number should be used to different data of gene expression.