基于天然氨基酸的双环手性季铵盐相转移催化剂的合成及催化性能研究

Synthesis and Catalytic Activities of Bicyclic Chiral Ammonium Salt Phase-Transfer Catalysts Based on Natural Amino Acids

以L-脯氨酸及L-羟基脯氨酸为原料合成了4个新型手性季铵盐类相转移催化剂,并用于催化不对称查耳酮环氧化反应,高产率得到相应环氧化合物,ee最高达9％。

Four chiral quaternary ammonium salts were designed and synthesized from naturally occurring L-proline and L-hydroxyproline. These compounds were employed as phase-transfer catalysts in asymmetric epoxidation reactions of chalcone affording the corresponding epoxide in high yields and up to 9% ee.