肾上腺皮质激素治疗小儿原发性肾病综合症的效应及其早期预测

Therapeutic Effect of Corticosteroid on Children's Primary Nephrotic Syndrome and Early Prediction

本研究根据64例小儿原发性肾病综合症的临床资料,通过对患儿的年龄、病程、尿蛋白选择性,有无血尿、肾功能及临床分型等与肾上腺皮质激素(简称激素)疗效比较,来早期预测患儿对激素的敏感性。秩和检验分析结果是:单纯性肾病,无血尿及肾功能正常者,激素疗效好(P<0.01);而肾炎性肾病,伴有血尿及肾功能不全者激素疗效差(P<0.01);另外患儿的年龄、病程、尿蛋白选择性与激素疗效无明显关系(P>0.05)。

This report is intended to the clinical data of 64 cases of children′s primary nephrotic syndrome (CPNS). We compared the patien′s age, CPNS course, selection of proteinuria, hematuria, renal function and clinical type with therapeutic effect of corticosteroid and predicted its early sensitivity. We found that ① To the patient with nephrotic syndrom-simple type, non-hematuria or normal renal function, corticostroid treatment was well effective (P<0.01). ② To the patient with nephrotic syndrome-nephrotic type hematuria or abnormal renal function corticosteroid treatment was less effective (P<0.01). ③The patient′s age, course, selection of proteinuria had no obvious relation therapeutic effect of corticosteroid (P>0.05).