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LIM-only转录因子研究进展 被引量:2

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摘要 LIM only转录因子是LIM基因家族中的LIM only基因编码的转录调节因子 ,其蛋白 (LMO蛋白 )结构中含 1个或多个LIM结构域。LIM结构域由两个串联重复的种间高度保守的LIM基元组成。现已发现属于该家族的基因主要有LMO1、LMO2、LMO3、LMO4、dLMO、XLMO、PDLP、FHL等 ,并且还会有新的发现。迄今的研究结果表明 ,LMO蛋白是一种蛋白相互作用的适配器 ,它的LIM结构域可与核内广泛分布的LIM结构域结合蛋白或其他的转录调节因子结合形成转录复合体 ,启动特异基因的转录 ,调节生物的发育和分化 。
作者 惠玲 蔡文琴
出处 《国外医学(分子生物学分册)》 CSCD 2003年第4期238-241,共4页
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参考文献18

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同被引文献27

  • 1Marshall E. Gene therapy death prompts review of adenovirus vector.Science, 2002; 286: 2244- 2245
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  • 4Snyder R. O., Miao C., Meuse L., et al. Correction of hemophilia B in canine and murine models using recombinant adeno - associated veral vectors. Nature Medicine, 1999; 5:64-70
  • 5Mark A. K., Catherine S. M., Margaret V. R., et al. Evidence for gene transfer and expression of factor in haemophilia B patients treated with an AAV vector. Nature Genetics, 2000; 24: 257- 261
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  • 9Marshall E. What to do when clear success comes with an unclear risk?Science, 2002; 298: 510-511
  • 10Marshall E. Second child in French trial is found to have Leukemia.Science, 2003; 299: 320

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