急性上呼吸道感染患儿外周血C-反应蛋白的测定及临床意义

Determination and clinical significance of peripheral blood C-reactive protein in children with acute upper respiratory tract infection

目的 探讨C 反应蛋白 (CRP)对急性上呼吸道感染患儿在诊断和治疗中的临床意义。 方法 选择 373例在急诊科就诊的患儿 ,采集指端全血 40 μL ,进行血常规检查 ,同时用免疫比浊方法进行C 反应蛋白检测 ,将测定的CRP结果与WBC计数做比较 ;将第二次、第三次测定的CRP结果与前次的CRP做比较。 结果 373例血标本中CRP <8mg/L 341例 ,占 91 4 2 %;CRP >10 0mg/L 4例 ,占 1 0 7%;CRP在 8～ 10 0mg/L 2 8例 ,占 7 5 1%;WBC计数在 10× 10 9/L以下 318例 ,占 85 2 6 %;CRP <8mg/L ,同时WBC数在 10× 10 9/L以上 35例 ,占 9 38%;CRP≥ 8mg/L ,同时WBC数在 10× 10 9/L以下 12例 ,占 3 2 2 %;第二次测定C 反应蛋白的 32例中较前次降低的为 30例 ;另 2例经调整治疗后第三次复查也较前次降低。 结论 CRP检测在急性上呼吸道感染患儿中对鉴别细菌或病毒感染以及判定抗生素疗效方面具有较高的价值 ,值得推广。

Objective To explore the clinical significance of C-reactive protein (CRP) test in diagnosis and treatment of patients with acute apper respiratory infection (AURI).Methods Three hundred and seventy-three cases with AURI tract infection treated in the emergency were measured by the immune comparison method.Then the tested result of CRP were compared with the number of WBC.Besides,the following CRP results were compared with the first CRP result.Results In the 373 cases,the CRP of 341 cases were <8?mg/L (91\^42%),4 cases were >100?mg/L (1\^07%);35 cases were <8?mg/L and their WBC number were over 10×10\+9/L(9.38%).CRP of 12 cases were ≥8 mg/L and their WBC number were beloro 10×10 9/L (3\^22%).In the 32 cases,whose CRP were tested in the 2nd time,30 cases were lower than the first time,the other two were also lower than the first time in the 3rd reexamination after the treatment.Conclusion CRP test is valuable in the different diagnosis of the bacteria or the virus infection and eraluation of the curative effect of the antibiotics among patients with AURI.