感染性疾病所致全身炎症反应综合征患儿血清酶变化的分析

The analysis of serum enzymology changes in patients with systemic inflammatory response syndrome caused by infectious disease

目的 分析血清酶变化在感染性疾病所致全身炎症反应综合征 (SIRS)患儿中的意义。 方法 测定 36例符合SIRS诊断标准的患儿血清肌酸激酶 (CK)及同工酶 (CK MB)、乳酸脱氢酶 (LDH)、门冬氨酸氨基转移酶 (AST)在不同时期的变化 ,并与同期住院无SIRS的感染性疾病患儿 12 6例对照。 结果 SIRS患儿CK及CK MB水平较对照组升高 (P <0 0 5 ) ,发生MODS和单器官功能不全时各酶水平进一步升高 (P <0 0 1)。 结论 动态监测SIRS患儿血清酶变化 ,有助于判别疾病的严重程度及预测MODS的发生。

Objective To explore the significance of serum enzymology in patients with systemic inflammatory response syndrome (SIRS) caused by infectious disease.Methods Serum CK,CK-MB,LDH,AST were measured in 36 cases with SIRS at 1～3 day and 5～10 day after hospitalization.126 patients without SIRS were chosen as the control group.Results The Serum CK,CK-MB concentrations of patients with SIRS were significantly different to the control group (P<0.05),when MODS or single organ dysfunction occurred,the level of CK,CK-MB,LDH,AST were obviously elevated(P<0\^01).Conclusion Monitoring the level of serum enzymology of SIRS is helpful to evaluate the severity of the disease and provide theoretical basis for prevention and management in early stage of MODS.