新生儿缺氧缺血性脑病预后与不同正常血糖浓度关系探讨

The relationship between prognosis of neonatal hypoxic-ischemic encephalopathy and different normal blood glucose levels

目的 分析正常血糖浓度的不同范围对新生儿缺氧缺血性脑病 (HIE)预后的影响 ,探讨改善预后的措施。 方法 对收治血糖正常浓度不同的 16 1例HIE患儿临床资料及随访结果进行分析。 结果 高浓度值的正常血糖HIE组 (高值组 )疗效及预后显著高于低浓度值的正常血糖HIE组 (低值组 ) (χ2 =4 0 33,P <0 0 5 ;χ2 =4 4 2 9,P <0 0 5 )。中浓度值的正常血糖HIE组(中值组 )与低值组比较 ,疗效及预后差异均无显著性 (χ2 =0 0 79,P >0 0 5 ,χ2 =0 0 2 0 1,P >0 0 5 )。 结论 早期诊治 ,维持内环境稳定 ,尤其是保持血糖浓度在正常的高值是提高HIE患儿疗效 ,改善其预后的重要方法之一。

Objective To explore the relationship between prognosis of neonatal hypoxic-ischemic encephalopathy and different normal blood glucose levels.Methods Clinical data of 161 cases of neonatal HIE with different normal blood glucose levels were analyzed.Results Effects and prognosis of the group with high normal blood glucose levels were much better than those of the low group (χ\+2=4.033,P<0.05,χ\+2=4.429,P<0.05).Conclusion Early diagnosis and clinical intervention,maintaining the hemostasis,particularly maintaining high normal blood-glucose levels can improve the effects and prognosis of neonatal HIE.