摘要
大量研究表明 ,氧化应激可导致细胞凋亡。目前对这一现象有四种解释 :ROS活化核转录因子KB并诱导核转录因子 -KB表达 ,导致细胞凋亡 ;线粒体介导的细胞凋亡 ;ROS导致DNA损伤 ,激活P5 3诱导细胞凋亡及ROS激活SAPK通路介导细胞凋亡。但从总体上看 ,其分子机制还不十分清楚 。
Many research findings revealed that oxidative stress may induce apoptosis. At present, the explanations for this phenomenon are: 1) ROS activated nuclear factor-KB and induction of the expression of nuclear factor-KB; 2) mitochondria-mediated cell apoptosis; 3) ROS mediated DNA damage and P53 activation; 4) ROS activated SAPK pathway to apoptosis. In this paper, the progress on oxidative stress and apoptosis was reviewed.
出处
《卫生研究》
CAS
CSCD
北大核心
2003年第3期276-279,共4页
Journal of Hygiene Research
基金
国家自然科学基金资助项目 (No .30 2 71 1 53)