血容量扩充药及其临床应用

Plasma Volume Extender and its Clinical Application

目的 :综述血容量扩充药的临床合理选药用药。方法 :通过检索中英文相关文献 ,从有效、安全、经济三方面对血容量扩充药各主要品种进行分析。结果 :从药效、不良反应和成本支出综合考虑 ,右旋糖酐 40及 70 6代血浆以价格优势保证较高的应用量 ,但有较高的不良反应发生率 ;血定安和贺斯的成本效果较为适中 ;人血白蛋白因其高昂的价格 ,及其血液制品的潜在危险性 ,并非扩充血容量的最佳选择。结论 :血容量扩充药应用日益增多 ,需从有效、安全、经济综合考虑 。

Objective: To review the rational selection and utilization of plasma volume extender in clinical application.Method: The efficacy, safety and economy of main kinds of plasma volume extender were analyzed through indexing its English and Chinese documents concerned.Result: Dextram 40 and Hydroxyethyl starch have been maintaining their high utilization due to their dominance in price despite higher rates of ADRs; the cost effectiveness of Gelofusine and Haes steril is appropriate considering their general consulting potency, DR reports and cost expenditure; seroalbumine humane is not the optimum selection because of its expensive price and potential hazards as blood products.Conclusion: Considered to be effective, safe and economical, the plasma volume extender should be rationally administrated because of its more and more application.