解热、镇痛、非甾体抗炎前药的合成

The Synthesis of Non—steroidal Antiinflammatory Prodrug as an Analgetics and Antipyretics

本文报道了以布洛芬为原料,与扑热息痛依次经取代、酯化等反应合成了一种具有解热、镇痛和抗炎作用的前体药物的方法。

In this paper, a prodrug(Ⅲ)as analgetics,antipyretics and antiinflammatory agent was synthesized parac etamol from Ibuprofen(Ⅰ)via acyl chloridization and esterfication.