分娩期应用硫酸镁对妊高征母儿预后的影响

EFFECT OF MAGNESIUM SULFATE FOR INTRAPARTUM TREATMENT ON MATERNAL AND NEONATAL OUTCOMES IN PATIENTS WITH PREGNANCY INDUCED HYPERTENSION

目的 :探讨妊高征患者分娩期应用硫酸镁对母儿预后的影响。方法 :回顾性分析近 10年来在该院分娩的妊高征患者分娩期应用硫酸镁情况的临床资料。结果 :分娩的妊高征患者共 82 6例 ,其中分娩期硫酸镁治疗组 4 2 2例 ,未治疗组 4 0 4例。轻、中、重度妊高征分娩期硫酸镁用量分别为 :4 .33± 1.14 g ;5 .5 0± 1.6 4 g ;9.0 0± 1.70g。不同程度妊高征硫酸镁治疗组与未治疗组比较 ,产程、产后出血量及新生儿窒息率差异均无显著意义 (P >0 .0 5 ) ,而两组中轻、中度妊高征分别与重度妊高征比较 ,产后出血量差异均有显著意义 (分别P <0 .0 1,P <0 .0 5 )。硫酸镁配伍酚妥拉明预防子痫 (n =89)较单用酚妥拉明治疗组 (n =5 4 )子痫发生率显著降低 (P <0 .0 5 )。结论 :妊高征患者分娩期适量应用硫酸镁对母儿是安全的 ,有利于预防子痫等并发症。

Objective:To investigate whether magnesium sulfate for intrapartum treatment affected maternal and neonatal outcomes in patients with Pregnancy induced hypertension (PIH).Methods:Retrospective data analysis about 826 PIH patients delivered in our hospital in last 10 years.Results:422 PIH patients were received magnesium sulfate for intrapartum treatment and 404 PIH patients were not received .The dose of magnesium sulfate in mild, moderate and severe PIH were respectively 4.33±1.14gram, 5.50±1.64 gram and 9.00±l.70gram. There was no significant difference in stages of labor,postpartum blood loss and anoxia of newborn between two groups in same degree PIH patients.But the Postpartum blood loss of severe PIH were increased significantly compared respectively with mild PIH and moderate PIH in each group ( P <0.01 , P <0.05 respectively).The incidence rates of eclampsia in severe PIH given both magnesium sulfate and phenolamine (n=89) for prevention of eclampsia were decreased significantly than severe PIH given single phenolamine(n=54).Conclusions:Proper dose of magnesium sulfate for intrapartum treatment was safe in PIH patients and there were advantages for prevention of complications, such as eclampsia, etc.