铅接触工人图形视诱发电位改变的研究

Study on the change of the pattern visual evoked potential in work-ers exposed to lead

目的 探讨视诱发电位检查对慢性铅中毒早期诊断的意义。方法 观察33例(66眼)铅接触工人图形视诱发电位改变特征,与30例(60眼)非铅接触工人的图形视诱发电位检测结果对比,并进行心理物理学检查分析。结果 铅接触工人与非铅接触工人之间图形视诱发电位的差异有显著性(P<0.01),表现为N_(75),P_(100),N_(145)潜伏期延长。多因素相关逐步回归分析结果表明,P_(100)潜伏期延长与铅接触工人尿中δ-氨基-γ酮戊酸呈显著正相关。结论 铅接触可致祝诱发电位的改变,图形视诱发电位可作为铅对视神经功能损害程度的非损伤筛选方法,也可作为铅中毒早期诊断的参考工具。

Objective To observe the characteristic of the pattern visual e-voked potential on workers exposed to lead, to know the significance of the check of pattern visual evoked potential to early lead poisoned clinic. Methods Analyze the check of pattern visual evoked potential and psychological physics with 33 (66 eyes) lead exposed workers and 30 (60 eye) non-lead exposed workers.Results The pattern visual evoked potential of lead exposed workers and non-lead exposed workers had significant difference (P < 0.01) , the latencies of N75 , P100, N145 waves were prolonged. The result of multi-factor relative and stepwise regression analysis showed that the latencies of P100 was positively relative to 8 -ALA in workers exposed to lead significanly. Conclusion Occupational lead exposure leads to the change of pattern visual evoked potential. Pattern visual evoked potential may be as non - invasie screening tool for lead damaging optic nerve function and as method for early clinic diagnosis in chronic lead poison.