趋化因子IP-10在慢性乙肝患者血清中的表达及意义

The expression and significance of chemokine interferon-inducible protein-10(IP-10) in chronic hepatitis B patients

为探讨趋化因子IP - 10在慢性乙肝患者的表达水平及其与肝细胞受损程度之间的关系 ,分别设立健康对照组 ,慢性乙肝中轻度组、重度组、慢性重型肝炎组 ,采用ELISA方法检测IP - 10、γ -IFN的血清浓度。并同时作常规生化检测。结果慢性乙肝各组IP - 10水平均高于对照组 ,且与ALT、AST呈正相关。表明慢性乙肝患者血清IP-

To clarify the role of IP-10 in Chronic Hepatitis B, we study the serum levels of IP-10 in chronic hepatitis B patients and chronic severe hepatitis patients. The correlation between the serum levels of IP-10 and clinical parameters was also evaluated. The serum levels of IP-10 was much higher in patients with chronic hepatitis B than in healthy controls, and it was significantly correlated with ALT?AST. The results suggest that the serum levels of IP-10 can reflect the damage of hepatocytes.