左氧氟沙星治疗耐多药肺结核近期疗效观察

The effect of Levofloxacin on treating MDR-TB

目的 观察左氧氟沙星对耐多药肺结核的近期疗效。方法 92例耐多药肺结核患者随机分为治疗组 5 0例和对照组 4 2例 ,化疗方案分别是 3HKZThV/18HZTh ,3HKZTh/18HZTh ,观察两组痰菌阴转、病变吸收和症状改善情况。结果 治疗组 3月和 6月的痰菌阴转率、病变吸收率、症状改善率分别是 4 0 .0 % ,5 8.0 % ;5 4.0 % ,72 .0 % ;6 6 .0 % ,76 .0 % ,对照组分别是 19.0 % ,35 .7% ;33.3% ,4 2 .9% ;38.1% ,4 5 .2 % ,两组之间有显著性差异 (P <0 .0 5 )。结论 左氧氟沙星联合其他化疗药物 3月强化治疗耐多药肺结核效果明显。

Objective To observe the effect of Levofloxacin on treating MDR-TB. Methods Divide 92 cases into two groups in a randomized way , 50 of them was study group , the rest was control group. Therapy for 2 groups were 3HKZThV/18HZTh and 3HKZTh/18HZTh respectively, then observe the changes in sputum bacteria , focus and symptoms of two groups.Results The rate of sputum bacteria negtive , focus shrinking and symptoms improving of study group were 40.0%,58.0%; 54.0% ,72.0%; 66.0%, 76.0% respectively after three months and six months. That of control group were 19.0%,35.7%;33.3%,42.9%;38.1%,45.2% respectively .There is significant difference between two groups(P<0.05).Conclusion Significant results were achieved when choosing Levofloxacin combined with other medicine for treating MDR-TB enforcedly.