综合重症监护病房医院内肺部真菌感染临床分析

Nosocomial Pulmonary Fungal Infection in ICU: A Clinical Investigation

目的 探讨综合重症监护病房 (ICU)医院内肺部真菌感染的临床特点及预后。方法 对 1999年 1月～2 0 0 1年 11月入住综合ICU ,诊断为肺部真菌感染的 36例患者 ,感染原因、真菌培养结果进行分析。结果 综合ICU医院内肺部真菌感染患者年龄、住ICU时间及APACHEⅡ评分皆高于非肺部真菌感染者 (P <0 .0 5 ) ,其基础疾病与普通病房有所不同 ,病原菌以白色念珠菌为主占 5 3% ,非白色念珠菌占 4 7% ,肺部真菌感染后死亡率高达 39%。结论 综合ICU医院内肺部真菌感染的基础疾病及真菌类型有自己的特点 ,并且有一定的诱发因素 ,应予以高度重视。

OBJECTIVE To investigate the characters and prognosis of noscomial pulmonary fungal infection in ICU. METHODS To analyze the features of 36 patients diagnosed nosocomial pulmonary fungal infection in ICU from Jan 1999 to Nov 2001. RESULTS The age, APACHEⅡ and the long time of hospitalization of the cases with nosocomial pulmonary fungal infection were higher than the indexes of the cases without nosocomial pulmonary fungal infection in ICU(P<0.05). Their underlying diseases were different from the cases with nosocomial pulmonary fungal infection in general ward. Some complications increased the rate of nosocomial pulmonary fungal infection.Candida albicans was ranked the first pathogen(53%). Non Candida albicans was ranked the second pathogens(47%). The mortality was 39%for the patients with pulmonary fungal infection. CONCLUSIONS The underlying diseases and the kind of fungi of the cases with nosocomial pulmonary fungal infection in ICU,have their own character and inducing factors to which clinicians should pay more attention.