高密度脂蛋白抑制L-选择素对心血管的保护作用

High density lipoproteins (HDL) protect cardiovascular effect by inhibiting activity of L-selectin

目的 从炎症反应的角度探讨 HDL 保护冠心病的机制。方法 冠心病患者 30例 ,健康对照组 19例 ,分别测定两组血清中可溶性 L-选择素 (L- selectin)和 HDL。结果 1冠心病组 HDL 水平 [(0 .74± 0 .33) mm ol/ L]较对照组 [(1.4 5± 0 .37) mm ol/ L]明显降低 (P<0 .0 5 ) ,而可溶性 L- selectin冠心病组 [(1.34± 0 .36 ) μg/ ml]较对照组 [(1.0 5± 0 .39)μg/ ml]明显升高 (P<0 .0 5 )。 2 4 9例受试者的可溶性 L - selectin和 HDL两者间呈明显负相关 (r=- 0 .88,P<0 .0 0 1)。结论 1冠心病组 HDL较对照组低 ,符合 HDL有心血管保护作用的理论。可溶性 L - selectin在冠心病组较对照组高表明 L - selectin参与冠心病的发作。 2 HDL与可溶性 L - selectin间有明显负相关性 ,表明HDL 有可能通过抑制 L-

s: Objective To investigate the relationship between HDL and soluble L-selectin(sL-selectin) to provide a new mechanistic explanation for protective effect of HDL on coronary heart diseases. Methods Serum concentrations of soluble L-selectin and HDL were measured in 30 patients with coronary heart disease and 19 healthy subjects. Blood samples were collected by vene-puncture. Results (1) Serum mean (±SD) levels of soluble L-selectin were increased (P<0.05) in patients with heart disease(1.34±0.36 μg/ml) compared with that [(1.05±0.39)μg/ml] in healthy subjects; while the levels of HDL[(0.74±0.33)mmol/L]were lower (P<0.05) in patients with heart disease. (2)There are high correlation between HDL and soluble L-selectin. Conclusion HDL has the protective function against coronary heart disease, and HDL may have their protective function by inhibiting the expression of L-selectin.