组织因子与冠心病

Tissue factor and coronary heart disease

组织因子作为因子 F /F a的细胞膜表面受体 ,是生理凝血过程中最重要的启动因子 ,许多炎性介质能诱导单核细胞、巨噬细胞、平滑肌细胞和血管内皮细胞表达组织因子。组织因子通过介导凝血激活形成血栓以及促进平滑肌细胞增殖和移行影响冠心病的发生和发展。本文对组织因子与动脉粥样硬化、血管成形术后再狭窄 ,心肌缺血及心肌缺血

Tissue factor(TF) is receptor for factor FⅦ/ FⅦa on the cell surface. It is an important initiator of the coagulation cascade situated within the vessel wall.Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing expression of TF in cells such as monocytes, macrophages, smooth muscle cells and endothelial cells. TF plays pivotal roles in thrombus formation and facilitates smooth muscle cell proliferation as well as migration, which is an important contribution in the pathogenesis of coronary artery disease. This review presents the current knowledge on the role of TF in atherosclerosis, restenosis after angioplasty and myocardial ischemia as well as myocardial injury during postischemic reperfusion.