雌、孕激素受体与P-糖蛋白在肺癌中的表达及其意义

Expression and its significance of estrogen receptor, progesterone receptor and P-glycoprotein in lung cancer

目的 :探讨ER、PR、P gP在肺癌组织中的表达情况 ,以及ER、PR与P gP之间的关系 ,为肺癌的优化化疗、预测预后提供有价值的指标。方法 :应用S P免疫组化法检测石蜡包埋的肺癌标本中ER、PR、P gP的表达。结果 :P gP阳性表达率36 0 5 %(31/ 86 ) ,ER、PR的阳性表达率分别为 39 5 3%、41 86 %,其中腺癌的表达明显高于其它组织类型。ER、PR的表达与肿瘤细胞分化水平呈正相关 ,而与患者的性别、年龄、临床分期无关。 31例P gP阳性病例中 ,EP、PR阳性表达率为 5 1 6 1%和6 4 5 2 %,肺癌组织中P gP与ER、PR的表达呈正相关。结论 :P gP与ER、PR之间可能存在某种相关性 ,提示肺癌的化疗若辅以性激素受体拮抗剂效果可能更好。

Objective:To investigate the correspondence between the expression of estrogen receptor(ER),progesterone receptor(PR) and P-glycoprotein(P-gp) in lung cancer.Methods:The immunohistochemical way S-P was employed to estimate the MDR1 (expressed as P-gp),ER and PR in lung cancer.Results:P-gp positive rate was 36.05%(31/86); ER and PR positive rates were 39.53% and 41.86%; its expression in lung adenocarcinoma was significantly higher than others. There were a significant correlation between ER and PR positive percentage and degrees of histological differentiation in lung cancer, while it has no relationship with clinical stage,age and sex of the patients. ER and PR positive rates were 51.61% and 64.52% in the 31 cases of P-gp positive. There was a closely positive correlation between the expression of P-gp and ER, PR.Conclusion:There was a relationship between the P-gp and ER,PR. Results show that the effect would be better combining the chemotherapy with sex hormones receptor in the treatment of lung cancer.