异长春花碱持续静脉输注治疗晚期非小细胞癌的临床观察

Clinical observation on continuous infusion of home-made vinorelbine with cisplatin for management of advanced or metastatic non-small cell lung cancer

目的 :观察异长春花碱静脉持续输注联合顺铂治疗非细胞肺癌的临床疗效及其毒副反应。方法 :42例晚期非小细胞肺癌患者随机分为治疗组 19例和对照组 2 3例。结果 :治疗组采用异长春花碱持续静脉输注给药 ,有效率为 47 3%;对照组采用异长春花碱常规静注给药 ,有效率为 43 5 %,二组比较无显著性差异 (P >0 0 5 )。两组主要毒性反应为骨髓抑制 ,白细胞减少发生率分别为 5 2 6 %和 86 9%,二组比较有显著性差异 (P <0 0 5 )。结论 :异长春花碱持续静脉输注联合顺铂与常规治疗方法相比有效率稍有提高 ,血液学毒性明显减低 ,采用锁骨下静脉置管避免了静脉炎的发生 ,降低了总的治疗费用 ,值得临床推广应用。

Objective:To observe the clinical effect and toxicity side effect brought from continuous administration of home-made vinorelbine with cisplatin in the treatment of patients with advanced or metastatic non-small lung cancer (NSCLC) by intravenous drip.Methods:42 patients with advanced or metastatic NSCLC were divided into home-made vinorelbine continuously curative group and conventionally curative group.Results:Response rate was 47.3% for the continuously curative group, or 43.5% for the conventionally curative group, showing no significant difference between the groups (P>0.05). As main toxic reaction, neutropenia incidences were 52.6% and 86.9% in the both groups, respectively, showing a significant difference (P<0.05).Conclusion:In comparison with conventional usage, continuous infusion of home-made vinorelbine with cisplatin showed evidently lower toxic reaction although improvement in its response rate was not especially satisfactory. Besides, administration through subclavian venae catheter may not only avoid chemo-phlebitis, but also reducte total curative expense, deserving to be further popularized.