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口服疫苗传递系统研究进展

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摘要 流感、结核、腹泻、肝炎、艾滋病等这些对人类生命与健康危害极大的和难以防治的重要传染病,都属于由粘膜入侵的疾病。为了防止感染,诱导粘膜表面产生分泌型IgA抗体(sIgA)是非常重要的。sIgA可以阻止微生物在粘膜上皮层驻扎繁殖,禁止它们进入上皮层。目前大多数疫苗都是经皮下或肌肉注射来接种的,通常无法诱导粘膜sIgA抗体的产生,只有通过粘膜表面接种疫苗才能有效地诱导粘膜免疫。粘膜免疫的途径有很多,但一般认为经口和经鼻免疫才是切实可行的。
出处 《沈阳部队医药》 2003年第4期338-340,共3页
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