β-酞酰亚胺基丙酸乙酯的合成研究

SYNTHESIS OF N-PHTHALYL-β-ALANINE ETHYL ESTER

采用相转移催化法 ,以 1,4 加成反应合成了 β 酞酰亚胺基丙酸乙酯。通过正交实验法 ,筛选出最佳反应条件为n(酞酰亚胺 )∶n(丙烯酸乙酯 )∶n(碳酸钾 ) =1∶1.8∶0 .2 5 ,1.7mL甲苯 /1g酞酰亚胺 ,0 .0 68g四丁基溴化铵 /1g酞酰亚胺 ,反应温度 94～ 96℃ ,反应时间 60min。在此条件下 ,产率 95 .3 %。

With the action of phase transfer agent, N phthalyl β alanine ethyl ester (PAEE) was synthesized. The optimal reaction conditions were selected through orthogonal experiments, i.e. n (phthalimide)∶ n ( ethyl acrylate)∶ n (K 2CO 3 )=1∶1.8∶0.25, 1.7 mL toluene/1 g phthalimide, 0.068 g TBAB/1 g phthalimide, the reaction temperature 9496 ℃, and the reaction time 60 min. Under these conditions the yield of PAEE is 95.3%.