摘要
目的 :观察慢性乙型肝炎 (慢乙肝 )患者血清TGFβ1、HA、肝功能和肝纤维化的关系。方法 :肝穿刺取得肝脏活体组织进行HE、网状纤维染色 ,了解纤维化程度。用ELISA法检测TGFβ1,用RIA法检测HA。结果 :(1)慢乙肝轻、中、重度及肝硬化患者血清TGFβ1水平分别为 16 .8± 6 .4 pg/mL、2 2 .7± 7.2 pg/mL、30 .2± 8.9pg/mL、37.9± 10 .7pg/mL明显高于对照组 8.2± 6 .8pg/mL ,且随着肝损害程度的加重逐渐升高 ;(2 )血清TGFβ1水平与TBIL呈正相关 ,与ALB呈负相关 ;(3)血清TGFβ1、HA水平随着肝组织纤维化程度的加重而增长。结论 :TGFβ1是慢性乙型病毒性肝炎肝纤维化形成的重要细胞因子之一。
Objective: to observe the relationship between TGFβ 1, HA Level and Hepatofibrosis in chronic hepatitis B. Methods: by performing hepatocentesis to get living tissue and then administering HE and reticular fibers staining to learn the extent of hepatofibrosis. Results: ①The levels of serum TGFβ 1 in mild, medium and severe chronic hepatitis B and hepatocirrhosis patients were 16.8±6.4pg/mL, 22.7±7.2pg/mL, 30.2±8.9pg/mL, 37.9±10.7pg/mL respectively, which were significantly higher than of control group (8.2±6.8pg/mL), and they got higher and higher with the advancing of hepatocirrhosis. ②Serum TGFβ 1 was correlated with serum levels of TBIL positively. ③The levels of serum TGFβ 1 and HA were raised with the development of fibrosis of hepatic tissues. Conclusion: TGFβ 1 is one of the important cell factors of hepatofibrosis in chronic virus hepatitis B.
出处
《牡丹江医学院学报》
2003年第4期10-13,共4页
Journal of Mudanjiang Medical University
