苦参素注射液治疗慢性乙型肝炎疗效观察

EFFECT OF MATRINE IN THE TREATMENT OF CHRONIC HEPATITIS B

目的 :观察苦参素对慢性乙型肝炎的疗效。方法 :随机将 10 5例分为苦参素治疗组 6 5例和对照组 4 0例。观察两组血清丙氨酸氨基转移酶 (ALT)、总胆红素 (TBiL)、白蛋白 (Alb)、Ⅲ型胶原纤维 (PCⅢ )、透明质酸 (HA)、层粘蛋白 (LN)和乙型肝炎病毒 (HBV)标志物。结果 :苦参素可明显降低慢性肝炎患者血清ALT、胆红素 ,PCⅢ、HA和LN水平 ,提高HBeAg阴转率、抗 -HBe阳转率和HBV -DNA阴转率 (P <0 .0 1)。 结论 :苦参素有保护肝细胞、减轻肝细胞坏死、防治肝纤维化和抗病毒作用。

Objective: To observe the therapeutic effectiveness of Matrine in the treatment of chronic hepatitis B. Method: 105 patients were divided into treatment group(65 cases) and control group(40 cases) at random. Observe Alanine aminotransferase(ALT), total bilirubin(TBiL), type Ⅲ procollagen (PCⅢ)、hyaluronic acid(HA), laminin(LN) and viral marker changes. Results: ALT, TBiL, PCⅢ、HA, LN were markedly decreased in the treatment group after treatment by Matrine. At the end of treatment the negative rate of HBeAg and HBV DNA, and the Positive rate of HBeAb in the treatment group was significantly higher than that of the control group(P<0.01). Conclusion: Matrine can protect the hepatic cells from injury and has the effect of antifibrosis and antiHBV.