早产儿和异常黄疸新生儿DPOAE检测

Analysis of the Results Using Distortion Product Otoacoustic Emissions Among Prematures Neonates and Pathological Jaundiced Neonates

[目的]比较正常新生儿、黄疸新生儿(新生儿病理性黄疸和高胆红素血症)和早产儿的畸变产物耳声发射(DPOAE)的检出率和幅值,以探讨黄疸及早产对听力的影响。[方法]对20例正常新生儿、37例的异常黄疸患儿及23例早产儿使用CELESTA 503进行DPOAE测试。[结果]①首次筛查仅f_0=1.0kHz、3.0kHz时的检出率差异有显著性,两两间比较显示正常组与早产组间的差异有显著性;②首次未通过耳3个月后再次复查,病理性黄疸组原未通过耳均通过再次筛查,仅早产儿组3例4耳仍未通过;③幅值比较显示f_0=2.0kHz、4.0kHz和6kHz时黄疸组的幅值高于早产组幅值,其差异有显著性;f_0=2.0kHz时正常组的幅值高于早产组幅值,其差异有显著性。[结论]新生儿病理性黄疸或高胆红素血症及时而有效治疗使体内胆红素增高的时间短而轻,对内耳外毛细胞的影响就可能较轻而且可恢复;早产对听力的影响较大。

[Objective] To investigate the effects of pathological jaundice and premature neonates through comparing the verifying-rates and amplitudes of distortion product otoacoustic emissions (DPOAES). [Methods] 20 healthy neonates, 37 pathological jaundice neonates and 20 premature neonates were tested using Celesta 503. [Results] (1) In the first test, the presence of DPOAE had a significant difference in the statistical analysis between the healthy neonate group and the premature neonate group using f0 = 1. 0 kHz, 3. 0 kHz; (2)After 3 months, all cases who didn't pass the first test were retest-ed , the pathological jaundice neonate group entirely passed , the premature neonate group had 3 cases 4 ears didn' t pass; (3) There was a significant difference in the statistical analysis in the amplitudes between the jaundice neonate group and the premature neonate group when f0 = 2.0 kHz, 4. 0 kHz, 6. 0 kHz; There was a significant difference in the statistical analysis in the amplitudes between the healthy neonate group and the premature neonate group when f0 = 3.0 kHz. [Conclusion] It was important that taking an immediate and effective therapy to decrease the concentration and the lasting time of the biliru-bin for these pathological jaundice neonates; The bilirubin maybe damage the outer hair cells slightly after taking the therapy so that the function of the outer hair cells can recover ; Premature maybe have a significant influence to hearing .