手性相转移催化剂的合成和不对称诱导效应

Synthesis and Asmmetric Induction Effect of Chiral Phase Transfer Catalysts

以氯霉素为原料 ,经水解、苄基化、季铵化合成了光学纯 ( 1 S,2 R) - ( - ) - 1 -对硝基苯基 - 1 ,3-二羟基 - 2 -丙基苄基二甲基溴化铵。作为相转移催化剂 ,它对苯乙腈的 α-甲基化。

S,2R) ( ) (1 para nitrophenyl 1,3 dihydroxyl 2 propyl)benzyldimethyla mmonium bromide was synthesized through hydrolysis,tert amination and quaterisation by using chloramphenicol as starting material.As a phase transfer catalyst, it shows a good catalysis and certain effect of asmmetric induction in α methylation of phenylacetonitrile and in addition of benzaldehyde with chloroform.