摘要
以氯霉素为原料 ,经水解、苄基化、季铵化合成了光学纯 ( 1 S,2 R) - ( - ) - 1 -对硝基苯基 - 1 ,3-二羟基 - 2 -丙基苄基二甲基溴化铵。作为相转移催化剂 ,它对苯乙腈的 α-甲基化。
S,2R) ( ) (1 para nitrophenyl 1,3 dihydroxyl 2 propyl)benzyldimethyla mmonium bromide was synthesized through hydrolysis,tert amination and quaterisation by using chloramphenicol as starting material.As a phase transfer catalyst, it shows a good catalysis and certain effect of asmmetric induction in α methylation of phenylacetonitrile and in addition of benzaldehyde with chloroform.
出处
《青岛科技大学学报(自然科学版)》
CAS
2003年第4期321-323,共3页
Journal of Qingdao University of Science and Technology:Natural Science Edition
关键词
手性相转移催化剂
合成
不对称诱导效应
氯霉素
原料
水解
苄基化
季铵化
phase transfer catalyst
synthesis
(1S,2R) (1 para nitrophenyl 1,3 dihydroxyl 2 propyl)benzyldimethylammonium bromide
asmmetric induction effect