机械通气的呼吸衰竭患者血清甲状腺素变化的意义

Significance of change of thyroxin in serum in respiratory failure patients with mechanical ventilation

目的 探讨机械通气的呼吸衰竭患者血清甲状腺素变化对病情严重程度、预后及脱机的意义。方法 对56例机械通气的呼吸衰竭患者测定机械通气前及脱机前的血清甲状腺素与血气分析。结果 机械通气的呼吸衰竭患者TT3、TT4、FT3、TSH均低于正常对照组 ,死亡组TT3、TT4、FT3、TSH、PaO2均低于存活组 ,脱机成功组TT3、TT4、FT3、TSH均恢复正常 ,脱机失败组血清甲状腺素持续低下 ,TT3、TT4、FT3 与PaO2 成正相关。结论 血清甲状腺素水平监测可反映呼吸衰竭患者病情的严重程度、预后 。

Objection To study the significance of thyroxin in serum to the severity of disease,prognosis and wean in respiratory failure patients with mechanical ventilation. Methods Total T3(TT3),total T4(TT4),free T3(FT3),free T4(FT4)thyroid-stimulating hormone(TSH)in serum and arterial partial pressure of oxygen(PaO2)were determined within mechanical ventilation and before wean. Results Serum TT3,TT4,FT3,TSH were significantly lower in respiratory failure patients than control.TT3,TT4,FT3,TSH in serum resumed if wean in success,TT3,TT4,FT3,TSH in serum lowcontinuously if wean in failure.There was a positive correlation between TT3,TT4,FT3,TSH in serumand PaO2. Conclusions Monitoring thyroxin in serumare of importance in reflecting of severity and prognosis of disease and in instructing of wean mechanical ventilation in patients with respiratory failure.