偏头痛的情感障碍及复方归辛冲剂的治疗作用

Emotional disturbance of migraine and therapeutical effect of Chinese herb mixture granule guixin

目的明确偏头痛有无情感障碍,观察中药方剂复方归辛冲剂对偏头痛的焦虑和抑郁症状有无治疗作用,以探讨药物的疗效机制。方法无先兆偏头痛患者及对照组各32例,发作间歇期分别进行焦虑自评量表(SAS)和抑郁自评量表(SDS)检测,给予归辛冲剂治疗1个月后复查SAS和SDS。结果偏头痛患者SAS及SDS平均标准分别为63±10及63±11,正常对照组分别为52±10及52±12,两组间均数比较t值分别为4.333及4.103,P值均为0.000。治疗后1个月,头痛改善有效率为95%,SAS及SDS分数无明显变化。结论偏头痛患者具有的焦虑和抑郁的情感障碍,可能是偏头痛的病因而非结果;归辛冲剂可显著改善偏头痛的症状但不能纠正其情感障碍。

Aim To confirm the affective disorder of migraineurs and to observe the effect of the Chinese herb mixture Granule Gui Xin on the depression and anxiety in migraineurs so as to explore its possible mechanism for migraine therapy.Methods Self rating Depression Scales(SDS) and Self rating Anxiety Scales(SAS) in interphase were conducted in 41 migraineurs without aura and cerebral and cardiac diseases, 9 males and 32 females, aged 16- 52 years old, and 32 normal volunteers, 10 males and 22 females, aged 20- 48 years old, used as controls. Then Granule Gui Xin were used to treat migraineurs for one month, and SDS and SAS were reviewed in patients.Results The standard scores of SAS in migraineur and control groups were 63± 10 and 52± 10 respectively (t=4.333,P=0.000). The standard scores of SDS in the two groups were 63± 11 and 52± 12 respectively.(t=4.103,P=0.000).The total effective rate of the herb therapy was 95% . After treatment, the SAS and SDS scores did not change significantly.Conclusion Migraineurs have prominent emotional disturbances such as anxiety and depression, which are supposed to be the possible etiological factor of migraine. The Granule Gui Xin improves the symptom of migraine except the emotional disturbances.