复合抗氧化剂对冠心病并糖尿病病人糖负荷后黏附分子表达的影响

Effect of Antioxidant on Expression of Adhesion Molecule in CHD and Type II Diabetes Mellitus

目的 探索不同剂量的大豆异黄酮 (Isoflavone)和维生素C、维生素E混合干预物对冠心病 (CHD)并 2型糖尿病 (T2 DM )病人糖负荷后血液中黏附分子表达的影响。方法 筛选出 85例已确诊的CHD并T2 DM病人 ,随机分为空白 (B组 )、低剂量 (C组 )、中间剂量 (D组 )和高剂量 (E组 )的大豆异黄酮和维生素C、维生素E混合干预物组 ,与正常人对照 (A组 )比较 ,同时进行OGTT ,观察不同研究对象糖负荷后餐前和餐后1、2、4、6h血液中黏附分子表达的影响。结果 OGTT过程中 ,A组、B组和C组血液中ICAM - 1、E -selectin都显著增高 ,而D组、E组废除了这种现象 ,2组间无显著差异。结论 高血糖可产生过氧化压力而引起血液中ICAM - 1、E -selectin的过度表达。由 1 5 0mg大豆异黄酮和 5 0 0mg维生素C、4 0 0IU维生素E组成的混合干预物 ,可作为CHD并T2 DM人群以防治动脉粥样硬化 (AS)

Objective To investigate the effect of different dosages of antioxidant (Isoflavone, Vitamin C and E) on the expression of adhesion molecules in CHD and Type II diabetes mellitus (T 2DM) patients. Methods 40 diagnosed CHD and T 2DM patients were randomly divided into zero dosage (B) group, low dosage (C) group, medium dosage (D) group and high dosage (E) group with mixture of soy isoflavone vitamin C and E, comparing with normal blood glucose control (A) group, taking OGTT and observing the effect on expression of adhesion molecules during the OGTT procedure of fasting and postpradial 1 h, 2 h, 4 h and 6 h respectively. Results During GTT, sICAM -1 and E-selectin were found increased in group A, B and C, but not in group D and E (P<0.05). Conclusion Glycemia could induce the over-expression of sICAM -1 and E-selectin due to oxidant. It was recommended to prevent CHD and T2DM complications such as atherosclerosis with the mixture at the dosage of 150mg soy isoflavone and 500mg vitamin C and 400 IU vitamin E.