雷尼替丁 胶体铋 克拉霉素治疗消化性溃疡幽门螺杆菌阳转阴的探讨

Discussion on Treatment of Peptic Ulcer Infected by Helicobacter Pylori with Ranitidine, Denol and Clarithromycin

目的 观察雷尼替丁 (RBC)、胶体铋、克拉霉素 3联疗法治疗消化性溃疡幽门螺杆菌 (Hp)阳性患者的近期疗效。方法 6 8例消化性溃疡幽门螺杆菌阳性的患者配对分组 ,治疗组 34例 ,给予RBC 4 0 0mg ,2次 /d口服 ,胶体铋 2粒 ,2次 /d口服 ,克拉霉素 2 5 0mg ,2次 /d口服。对照组 34例 ,给予奥美拉唑 2 0mg ,2次/d口服 ,克拉霉素 2 5 0mg ,2次 /d口服。治疗组与对照组治疗疗程均为 1周。观察 1周、8周、6个月后的幽门螺杆菌的Hp根除率 ,消化性溃疡愈合情况、幽门螺杆菌的再感染率及消化性溃疡复发率。结论 治疗组与对照组在幽门螺杆菌根除率、消化性溃疡愈合情况、幽门螺杆菌的再感染率及消化性溃疡复发率比较 ,2种治疗方案经统计学处理 ,无明显差别 (P >0 0 5 )。

Objective To observe the short term curative effect of peptic ulcer infected by helicobacter pylori (Hp) treated with ranitidine, denol and clarithromycin. Methods 68 cases of peptic ulcer patient infected by Hp were divided into treatment group and control group. The ranitidine, denol and clarithromycin were given in treatment group and omeprazole and clarithromycin were given in control group for a week. The remove rate of Hp, ulcer healing, reinfection of Hp and relapse of ulcer after week, 8 weeks and 6 months were observed. Results and conclusion The remove rate of Hp, ulcer healing, reinfection of Hp and relapse of ulcer were compared in two groups and there was no significant difference between two groups (P>0.05) after statistics treatment.