丙型肝炎患者血清TGF-β_1检测的临床意义

Clinical significance of detection of serum TGF-β_1 in patients with hepatitis C

目的 探讨转化生长因子 TGF-β1 在丙型肝炎患者中的发生和发展的作用。方法 应用酶联免疫吸附 ( EL ISA)方法对 4 0例丙型肝炎患者进行了血清 TGF- β1 含量测定 ,并与 35名正常健康人作对照。结果 丙型肝炎患者血清 TGF- β1 含量高于正常人组 ,且与肝功能损伤指标 AL T、TBi L 呈正相关。结论 测定丙型肝炎患者血清中 TGF-β1 含量对判断患者的病情变化具有十分重要的临床价值。

Objective To explore the effect of transforming growth factor β 1(TGF β 1) on the development of hepatitis C.Methods Level of TGF β 1 in serum were detected with ELISA method in 40 patients with hepatitis C and 35 normal controls.Results The level of TGF β 1 in patients with hepatitis C was higher than that in the normal controls( P <0.01).Significant positive correlation was found between serum levels of TGF β 1 and serum ALT and total bilirubin.Conclusion Detection of serum TGF β 1 might be one of the important parameters for clinical evaluation in patients with hepatitis C.