急性颅脑损伤后血清胰岛素、胰高血糖素、C肽、血糖的变化及其临床意义

Changs in Serum Insulin、Glucagon、C-peptide, Blood Glucose and Their Clinical Significance After Acute Brain Injury

目的探讨血清中胰岛素、胰高血糖素、C肽及血糖与颅脑损伤的关系及其临床意义。方法应用放射免疫法及生化分析法检测108例急性颅脑损伤患者血清胰岛素、胰高血糖素、C肽及血糖水平的变化,并与对照组比较。结果颅脑损伤急性期血清胰岛素、胰高血糖素、C肽及血糖均高于对照组,且颅脑损伤越严重,上述指标变化越明显。上述变化越明显,则病人预后越差。结论颅脑损伤急性期血糖及相关激素有明显改变,且其改变大小与颅脑损伤程度及预后呈正相关。

Objective To study the relationship between the changes in levels of serum insulin,glucagon,c-peptide,blood glucose and acute brain injury.Methods The levels of serum insulin,glucagons and c-peptide were determined by radioimmunoassay and the blood glucose by biochemical analysis in the 108 patients with acute brain injury.Results The levels of serum insulin, glucagon,c-peptide and blood glucose were significandy higher in the patients with acute brain injury than those in the control group (P<0.05).The more serious the acute brain injury was,the more significant the changes in the levels of serum insulin,glucagon,c-peptide, blood glucose were.Conclusions The changes in serum insulin,glucagon,c-peptide and blood glucose are related the severity of brain injury in the patients with acute brain injury.