荷叶胶囊对人体血脂异常的调脂作用研究

Effects of lotus leaf capsule on human's blood lipids disorder

目的:探讨荷叶水提物对人体血脂异常的调脂作用。方法:从郴州市各类人员体检检出的高脂血症者中,选择符合高血脂诊断标准的自愿者,共90人。随机分成3组,每组30人,即荷叶胶囊组(A组),洛伐他汀组(B组)和对照组(C组)。A组服用荷叶水提物制作的胶囊,4粒/次,3次/d;B组服用洛伐他订,20mg/次,1次/d,C组给予安慰剂;各组均进行健康教育和膳食指导,调脂40天。采用日本产全自动生化分析仪(OLYMPUS-640)测定调脂前、后的血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平。结果:A组调脂后血清TC、TG、LDL-C水平明显下降,HDI-C水平明显升高,与调脂前比较有显著差异(P<0.001.<0.001,<0.002,<0.01);B组调脂后TC、TG、LDL-C水平亦明显下降(P<0.001,<0.05,<0,001),与A组无显著差异(P>0.05),但升高HDL-C效果不明显(P>0.05);C组调脂前、后血清TC、TG、LDL-C和HDL-C水平无显著差异(P>0.05),且调脂后的血脂水平明显高于A、B组(P<0.01)。结论;荷叶水提物对人体具较好的调脂作用,且无毒,未发现副作用。

Objective: To explore the role of water extract of lotus leaf to improve human's blood lipid disorder. Methods: Ninety hyperlipemia volunteers choosing from health examination of Chenzhou inhabitants were randomly divided into 3 groups with 30 cases in each group: Lotus leaf capsule group (group A), lovastatin group (group B) and control group (group C). The test period was 40 days. Lotus leaf capsule was taken 3 times every day with 4 pills each time in group A; lovastatin was taken 1 time every day with 20mg each time in group B; placebo was taken in group C. Health education was given in every group. The blood lipids (TC, TG, HDL-C. LDL-C) were measured by OLYMPUS-640 before and after treatment. Results: In group A, the serum level of TC, TG, LDL-C after treatment was lower, the HDL-C was higher than those of before treatment (P<0. 001, P<0. 0001, P<0. 002, P <0. 01); In group B, there were significant effects on decreased blood lipid as group A (P<C 0.001, <0. 05. < 0. 001), there was no significant difference between A and B groups (P>0. 05). The effect to increase HDL-C wasn't obvious (P>0. 05) in group B. In group C, there was not significant difference in serum level of TC, TG, LDL-C.. HDL-C before and after treatment (P>0, 05). Conclusion; The water extract of lotus leaf can improve blood lipid disorder without any toxicity.