冠心病患者左心功能的改变

Change of left ventricular cardiac function in patients with coronary artery disease

目的:观察不同程度冠心病患者左心功能的变化。方法;78例冠心病患者分成稳定性心绞痛(SA)、不稳定性心绞痛(UA)、急性心肌梗死(AMI)和陈旧性心肌梗死(OMI)4组,并与30例健康成人(对照组)比较。采用无创伤自动检测仪及彩色多普勒血流显像仪测定心功能指标;心排血指数(CI),外周阻力(TPR),左室射血前期(PEP)及左室射血时间(LVET);左室收缩功能:射血分数,每搏量,心搏出量;左室舒张功能:A峰,E峰,峰值速度比值,峰值充盈,标准化充盈速度。结果:AMI和OMI组心功能明显减低(P<0.01):CI减少,TPR增高,PEP延长,LVET缩短,左室收缩功能减弱,舒张功能降低;UA和SA组心功能减低(P<0.05～<0.01);AMI和OMI组比UA和SA组心功能减低有显著差异(P<0.05)。结论;冠心病随病情加重,心功能明显恶化。

Objective: To examine change of left ventricular cardiac function in patients with coronary artery disease. Methods.- Seventy-eight inpatients with coronary artery disease (CAD) complicated with left ventricular dysfunction were divided into stable angina pectoris (SA), unstable angina pectoris (UA), acute myocardial infarction (AMI), old myocardial infarction (OMI) groups.Cl, TPR, PEP, LVET. EF. SV, CO. A peak, E peak, PER, NPERs-1 were measured by noninvasive autonomic detector and color Doppler eehocardiography. Results: Compared with control group left ventricular function (CI, EF, SV, CO, E peak, PER and NPERs-1) significantly decreased (P <0. 01, all), TPR, PEP/LVET, A peak and A/E increased (P<0. 01, all) in OMI and AMI groups; left ventricular function decreased in UA and SA groups (P<0. 05-<0. 01). The decrease of left ventricular function in AMI and OMI groups was more than those of UA and SA groups (P<0. 05). Conclusion; Left ventricular dysfunction is association with severity of coronary artery disease.