C反应蛋白与肌钙蛋白测定对于不稳定性心绞痛的诊断价值

Value of C-reactive protein and troponin diagnosing unstable angina pectoris

目的:观察不稳定性心绞痛(UAP)与C反应蛋白(CRP)、肌钙蛋白(cTnT)的关系。方法;测定38例UAP患者(UAP组),35例稳定性心绞痛患者(SAP组)及32例健康对照组的CRP、cTnT和血脂水平,并进行比较,测定比较UAP组治疗前、后的CRP、cTnT水平。结果;UAP组与SAP组、对照组比较,其CRP、cTnT水平显著升高(P<0.05～0.01);UAP组的CRP、cTnT阳性率分别是42.8％、28.5％,两者比较有显著差异(P<0.05)。UAP组、SAP组血脂水平无显著差异(P>0.05),而与对照组相比均有显著差异(P<0.05);UAP组治疗后CRP、cTnT值显著下降(P分别<0.05,<0.01)。结论:UAP的触发因素可能与感染有关,CRP在UAP诊断中的敏感性比cTnT的高。动态观察CRP及cTnT有助于UAP疗效、预后的判断。

Objective: To study the correlation among unstable angina pectoris (UAP) and C-reactive protein (CRP), troponin (cTnT). Methods; The levels of CRP, cTnT and blood lipid were measured and analysis in 38 patients with unstable angina pectoris (UAP group), 35 patients with stable angina pectoris (SAP group) and 32 heath persons (control group). Results: Compared with SAP, control groups the levels of CRP and cTnT increased (P<0. 05, < 0. 01) in UAP group. The positive rate of CRP (42. 8%) was more than that of cTnT (28.5%) in UAP group. Compared with control group, the level of blood lipid significantly increased in UAP and SAP group (P<0. 05), but the level of blood lipid was no significant difference between UAP and SAP group (P>0. 05). After therapy the levels of CRP and cTnT decreased (P<0. 05, <0. 01) in UAP group. Conclusion: Trigger factor of SAP may associate with infection. Monitoring the levels of CRP and cTnT may contribute to diagnosis and evaluate prognosis of UAP.