C反应蛋白对冠心病的应用价值

The Applied Value of C-Reactive Protein in Coronary Artery Disease

目的 :探讨 C反应蛋白 (CRP)测定在冠心病中的应用价值。方法 :测定 1 0 6例冠心病患者和 1 0 6例与之性别、年龄相匹配的正常对照者的 CRP、白细胞 (WBC)、纤维蛋白原 (FIB)及血脂水平 ,记录吸烟史、高血压病及糖尿病史 ,并计算体重指数 (BMI)。其中冠心病组又分为 3组 ,急性心肌梗死 (AMI)组 2 6例 ,不稳定心绞痛 (UAP)组 4 1例 ,SAP(稳定性心绞痛 )组 39例。比较冠心病组各组间及与对照组之间 CRP等的差异。结果 :冠心病组 CRP和 WBC水平高于对照组 (P分别为 0 .0 0 9和 0 .0 1 7) ,经调整性别、年龄、 BMI、吸烟史、高血压病及糖尿病史、血脂指标后 ,CRP和WBC水平仍与冠心病患病率显著相关 ,OR分别为 1 .72 6和 1 .4 70 (P分别为 0 .0 4 8和 0 .0 36 )。 AMI组及 UAP组CRP水平与对照组相比有显著性差异 (P=0 .0 34,P<0 .0 0 1 ) ;U AP组与 SAP组相比 ,CRP水平也有显著性差异 (P=0 .0 1 1 ) ;而 SAP组与对照组相比 CRP水平则无明显差异 (P>0 .0 5 )。结论 :CRP水平升高是冠心病的独立危险因素。

Objective:To assess the applied value of C-Reactive Protein(CRP) in Coronary Artery Disease(CAD) Methods:The level of CRP, white blood cell (WBC),fibrinogen(FIB) and serum lipid in 106 patients with CAD and 106 healthy controls matched with CAD patients for sex and age range were assessed The body mass index(BMI) from patients' weight and height were computed The patient history inquiring about smoking habits,diabetes and hypertension were taken from every patient The patients with CAD were divided into three groups,26 cases of acute mycocardial infarction(AMI group),41 cases of unstable angina pectoris (UAP group),39 cases of stable angina pectoris(SAP group) The level of CRP,FIB WBC and serum lipid in three subgroups with that in controls were compared Results:The level of CRP and WBC in CAD group were higher than those in control group After adjuted for sex,age,BMI,smoking habits,diabetes,hypertension and serum lipid,CRP was correlated with CAD,the Odds Radio were 1 726 and 1 470 The levels of CRP in AMI group and UAP group were higher than that in control group The level of CRP in UAP group was higher than that in SAP group too There was no significant difference in the level of CRP between SAP group and control group Conclusion:Elevated CRP is an independent risk factor for CAD The level of CRP can reflect the disease degree in patients with CAD